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NATIONAL STEROID AUDIT

A national audit found that 14% of IBD patients experienced steroid excess.

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NATIONAL STEROID AUDIT1

National-Steroid-Audit-14-1

14% of IBD patients
exposed to steroids
experienced steroid excess

LOCAL STEROID AUDIT2

National-Steroid-Audit-14-1

It was found that the
percentage of IBD patients
experiencing steroid excess
was higher in the local audit
than the national audit average

*According to ECCO guidelines, steroid excess is defined as >2 steroid courses within the preceding 12 months or disease flare on steroid withdrawal or within 3 months of stopping steroids2,9 †49% of patients diagnosed with UC. ‡52% of patients diagnosed with UC. Numbers are rounded to the nearest whole number.

NatSteroidAudit-SideImage-1

SYSTEMIC STEROIDS
HAVE A POOR SAFETY PROFILE3,4

Short-term side effects of systemic steroids3-5
  • Acne
  • Increased appetite
  • Moon face
  • Weight gain
  • Mood problems
Long-term side effects of prolonged systemic steroid use3-6
  • Diabetes
  • Osteoporosis
  • Peptic ulceration
  • Oesophageal ulceration
  • Skin thinning
  • Confusion, irritability, delusions
    and suicidal thoughts
  • Glaucoma
  • Proximal myopathy
  • Hypertension
An alternative: Targeted topical oral steroid treatments

CORTIMENT® maintains the efficacy of corticosteroids while minimising systemic side effects7

STEROID EXCESS OVERVIEW*

Long-term systemic steroid use is associated with a wide range of side effects

 

CONSEQUENCES OF GLUCOCORTICOID EXCESS: AN OVERVIEW8

X

1. BRAIN/CNS

Induces depression and psychosis

X

2. CARBOHYDRATE/LIPID METABOLISM

⬆︎Hepatic glycogen deposition

⬆︎Peripheral insulin resistance

⬆︎Gluconeogenesis

⬆︎Free fatty acid production

Overall diabetogenic effect

X

3. ADIPOSE TISSUE DISTRIBUTION sarath

Promotes visceral obesity

X

4. BONE AND CALCIUM METABOLISM

⬇︎Bone formation

⬇︎Bone mass and osteoporosis

X

5. SKIN/MUSCLE/CONNECTIVE TISSUE

Protein catabolism/collagen breakdown

Skin thinning

Muscular atrophy

 
 
 
 
 
 
 
 
 
 
Page-89-MAN-only-1HIGHLIGHT-e1567418224887
X

6. ENDOCRINE SYSTEM

⬇︎LH, FSH release

⬇︎Thyroid stimulating hormone release

⬇︎Growth hormone secretion

X

7. EYE

Glaucoma

X

8. GASTROINTESTINAL TRACT

Peptic ulcerations

X

9. CARDIOVASCULAR/RENAL

Salt and water retention

Hypertension

Growth and Development

⬇︎Linear growth

Immune System

Anti-inflammatory action

Immunosuppression

CNS = Central nervous system;
LH = Lutenising hormone;
FSH = Follicle-stimulating hormone.

 

Adapted from Steward P, et al. Williams Textbook of Endocrinology.2011:479-544.

CORTIMENT® PATIENT VIDEO

‘Living with Ulcerative Colitis: A CORTIMENT® Patient Story’
Hear a patient’s experience of
living with UC, from coming to
terms with their diagnosis to
starting on 5-ASA treatment to
managing flares with CORTIMENT®
  • Raine T, et al. Gut. 2016;7(1):A1–A310 OC–080.
  • Data on file. Ferring UK Ltd.
  • Danese S, et al. Aliment Pharmacol Ther. 2014;39:1095–1103.
  • Prednisolone 5 mg Tablets. SmPC.
  • Mahadevan U, et al. Clinics in Colon and Rectal Surgery.2004;17(1):7–19.
  • Liu D, et al. Allergy, Asthma and Clinical Immunology.2013;9:30.
  • Travis SPL, et al. Gut. 2014;63:433–41. doi:10.1136/gutjnl-2012-304258.
  • Stewart P, et al. Williams Textbook of Endocrinology. Philadelphia, PA: Elsevier Saunders; 2011:479–544.
  • Harbord M, et al. J Crohns Colitis. 2017:769–784. doi:10.1093/ecco-jcc/ jjx009.
How Cortiment Works
Ulcerative Colitis
iSTART
Prescribing Cortiment
Resources

Job Code: UK-COR-2200001 - Date of preparation: January 2022

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