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“There is a suggestion in some studies and a SR and meta-analysis that cardiovascular side effects are less frequent in patients treated with LHRH antagonists than patients treated with LHRH agonists therefore patients with pre-existing cardiovascular disease or other cardiovascular risk factors might be considered to be treated with antagonists if a chemical castration is chosen”.
Use of a GnRH antagonist may be considered in men with a prior history of myocardial infarction or stroke, or with significant cardiac comorbidities
“It might be time to consider treating men who have pre-existing CV risk factors with a GnRH antagonist rather than an agonist.’’ 14
Adapted from Davey P and Alexandrou P. 202210